Development and Characterization of Griseofulvin Nanosponges to Enhance Bioavailability

The pharmaceutical industries are more interested in development of novel drug delivery system to overcome the disadvantages traditional system. Now a days, fungal infections increasing worldwide. Hence demand dosage form is increased with improved therapeutic effect and minimum side effect. main aim this study was develop griseofulvin loaded ß -cyclodextrin based nanosponges for improving dissolution, oral bioavailability. In present study, Nano sponges were prepared by emulsion solvent diffusion method. six different formulation batches formulated varying concentration ratio polymer. Preformulation done UVvisible spectrophotometer. Drug, polymer excipient compatibility studies analyzed FTIR studies. Nanosponges evaluated particle size, zeta potential, polydispersity index, scanning electron microscopy in-vitro release SEM showed highly porous structure having sponges-like shape. entrapment efficiency optimized batch F4 found be 97.69±0.006%. size potential 488.59nm -20.77 respectively. maximum 75.56% 8 hrs. current successfully developed - cyclodextrin improve dissolution rate, bioavailability masking bitter taste. used preparation shows efficient release. Griseofulvin prolonged which beneficial chronic infection. Another advantage formulating forms reduction dose, dosing frequency reduced effects.